Publications

2021

Biomolecules Orchestrating Cardiovascular Calcification.
Tintut Y, Honda HM, Demer LL.
Biomolecules. 2021 Oct 7.
Lipids and cardiovascular calcification: contributions to plaque vulnerability.
Hsu JJ, Tintut Y, Demer LL.
Curr Opin Lipidol. 2021 Oct 1
The Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease.
Islam S, Boström KI, Di Carlo D, Simmons CA, Tintut Y, Yao Y, Hsu JJ.
Front Physiol. 2021 Sep 9.
Hearts of Stone: Calcific Aortic Stenosis and Antiresorptive Agents for Osteoporosis.
Demer LL, Tintut Y.
Circulation. 2021 Jun 22
Potential impact of the steroid hormone, vitamin D, on the vasculature.
Tintut Y, Demer LL.
Am Heart J. 2021 Sep
A biomarker for vascular calcification: shedding light on an unfinished story?
Hsu JJ, Tintut Y, Demer LL.
Cardiovasc Res. 2021 Jul 7
Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice.
Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2021 Apr
Serotonin receptor type 2B activation augments TNF-α-induced matrix mineralization in murine valvular interstitial cells.
Fong F, Xian J, Demer LL, Tintut Y.
J Cell Biochem. 2021 Feb

2020

Changes in microarchitecture of atherosclerotic calcification assessed by ¹⁸F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice.
Hsu JJ, Fong F, Patel R, Qiao R, Lo K, Soundia A, Chang CC, Le V, Tseng CH, Demer LL, Tintut Y.
J Nucl Cardiol. 2021 Oct

2019

Regulation of calcific vascular and valvular disease by nuclear receptors.
Sallam T, Tintut Y, Demer LL.
Curr Opin Lipidol. 2019 Oct
Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease. Demer LL, Tintut Y.
Trends Endocrinol Metab. 2019 Sep
Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK.
JCI Insight. 2019 Apr 11

2018

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges.
Tintut Y, Hsu JJ, Demer LL.
Front Cardiovasc Med. 2018 Nov 23
Multiscale light-sheet for rapid imaging of cardiopulmonary system. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK.
JCI Insight. 2018 Aug 23
Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. Demer LL, Hsu JJ, Tintut Y.
Circ Res. 2018 May 25
Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y.
Am J Physiol Heart Circ Physiol. 2018

2017

Rigor and Reproducibility in Analysis of Vascular Calcification.
Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT.
Circ Res. 2017 Apr 14
Reply: Evolutionary approach sheds light on the significance of vascular calcification. Demer LL, Tintut Y.
Trends Cardiovasc Med. 2017 Jan

2016

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.
JCI Insight. 2016 Nov 3
Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification. Hsu JJ, Lim J, Tintut Y, Demer LL.
Heart. 2016 Nov 1
Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis. Lim J, Ehsanipour A, Hsu JJ, Lu J, Pedego T, Wu A, Walthers CM, Demer LL, Seidlits SK, Tintut Y.
Am J Pathol. 2016 Sep
COMP-lex Mechanics: Matricrine Signaling. Tintut Y, Demer LL.
Circ Res. 2016 Jul 8

2015

Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification.
Lim JJ, Li X, Lu J, Pedego TM, Demer L, Tintut Y.
J Cell Biochem. 2015 Apr 10.
Exosomes: nanosized cellular messages.
Tintut Y, Demer LL.
Circ Res. 2015 Apr 10;116(8):1281-3.
The leading edge of vascular calcification.
Demer LL, Tintut Y.
Trends Cardiovasc Med. 2015 May;25(4):275-7.

2014

Hyperlipidemia affects multiscale structure and strength of murine femur.
Ascenzi MG, Lutz A, Du X, Klimecky L, Kawas N, Hourany T, Jahng J, Chin J, Tintut Y, Nackenhors U, Keyak J.
J Biomech. 2014 Jul 18;47(10):2436-43.
Inflammatory, metabolic, and genetic mechanisms of vascular calcification.
Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):715-23.
FGF23 protein expression in coronary arteries is associated with impaired kidney function.
Van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K.
Nephrol Dial Transplant. 2014 Jan 23. IN PRESS
Inflammatory, metabolic, and genetic mechanisms of vascular calcification.
Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):715-23.
Effects of bioactive lipids and lipoproteins on bone.
Tintut Y, Demer LL.
Trends Endocrinol Metab. 2014 Feb;25(2):53-9.
Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts.
Li X, Garcia J, Lu J, Iriana S, Kalajzic I, Rowe D, Demer LL, Tintut Y.
J Cell Biochem. 2014 Jan;115(1):179-88.

2013

The Effects of Hyperlipidemia on Implant Osseointegration in the Mouse Femur.
Keuroghlian A, Barroso AD, Kirikian G, Bezouglaia O, Tintut Y, Tetradis S, Pirih FQ, Aghaloo T.
J Oral Implantol. 2013 Dec 2. IN PRESS
Introduction to the Compendium on calcific aortic valve disease.
Heistad DD, Shanahan C, Demer LL.
Circ Res. 2013 Jul 5;113(2):176-8.
Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice.
Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y.
Biochem Biophys Res Commun. 2013 Feb 1;431(1):19-24.
Regulatory circuits controlling vascular cell calcification.
Sallam T, Cheng H, Demer LL, Tintut Y.
Cell Mol Life Sci. 2013 Sep;70(17):3187-97.

2012

Atmospheric ultrafine particles promote vascular calcification via the NF-κB signaling pathway.
Li R, Mittelstein D, Kam W, Pakbin P, Du Y, Tintut Y, Navab M, Sioutas C, Hsiai T.
Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C362-9.
Preferred mitotic orientation in pattern formation by vascular mesenchymal cells.
Wong MN, Nguyen TP, Chen TH, Hsu JJ, Zeng X, Saw A, Demer EM, Zhao X, Tintut Y, Demer LL.
Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1411-7.
Enhanced mineralization potential of vascular cells from SM22α-Rankl (tg) mice.
Morony S, Sage AP, Corbin T, Lu J, Tintut Y, Demer LL.
Calcif Tissue Int. 2012 Dec;91(6):379-86.
Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells.
Chen TH, Zhu X, Pan L, Zeng X, Garfinkel A, Tintut Y, Demer LL, Zhao X, Ho CM.
Biomaterials. 2012 Dec;33(35):9019-26.
Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells.
Cheng H, Reddy A, Sage A, Lu J, Garfinkel A, Tintut Y, Demer LL.
J Vasc Res. 2012;49(5):441-6.
Patterns of periodic holes created by increased cell motility.
Chen TH, Guo C, Zhao X, Yao Y, Boström KI, Wong MN, Tintut Y, Demer LL, Ho CM, Garfinkel A.
Interface Focus. 2012 Aug 6;2(4):457-64.
Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics.
Chen TH, Hsu JJ, Zhao X, Guo C, Wong MN, Huang Y, Li Z, Garfinkel A, Ho CM, Tintut Y, Demer LL.
Circ Res. 2012 Feb 17;110(4):551-9.
A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases.
Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK.
Am J Physiol Cell Physiol. 2012 Feb 15;302(4):C658-65.
Adverse effects of hyperlipidemia on bone regeneration and strength.
Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, Tetradis S, Demer L, Aghaloo T, Tintut Y.
J Bone Miner Res. 2012 Feb;27(2):309-18.

2011

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM.
Circulation. 2011 Oct 18;124(16):1783-91.
Role of cellular cholesterol metabolism in vascular cell calcification.
Geng Y, Hsu JJ, Lu J, Ting TC, Miyazaki M, Demer LL, Tintut Y.
J Biol Chem. 2011 Sep 23;286(38):33701-6.
The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification.
Demer L, Tintut Y.
Circ Res. 2011 Jun 10;108(12):1482-93.
Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids.
Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y.
J Bone Miner Res. 2011 Jun;26(6):1197-206.
Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells.
Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M.
J Biol Chem. 2011 Jul 8;286(27):23938-49.
Thematic series on the pathobiology of vascular calcification: an introduction.
Towler DA, Demer LL.
Circ Res. 2011 May 27;108(11):1378-80.
The hemosteoblast: friend or foe?
Tintut Y, Demer L.
Circ Res. 2011 Apr 29;108(9):1038-9.
Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages.
Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y.
Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1387-96.
Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro.
Sage AP, Lu J, Tintut Y, Demer LL.
Kidney Int. 2011 Feb;79(4):414-22.

2010

Regulatory mechanisms in vascular calcification.
Sage AP, Tintut Y, Demer LL.
Nat Rev Cardiol. 2010 Sep;7(9):528-36.
PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.
Tseng W, Graham LS, Geng Y, Reddy A, Lu J, Effros RB, Demer L, Tintut Y.
J Biol Chem. 2010 Sep 24;285(39):29925-31.
The bone-vascular axis in chronic kidney disease.
Demer L, Tintut Y.
Curr Opin Nephrol Hypertens. 2010 Jul;19(4):349-53. REVIEW
Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids.
Tseng W, Lu J, Bishop GA, Watson AD, Sage AP, Demer L, Tintut Y.
J Lipid Res. 2010 May;51(5):1010-6.

2009

Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.
Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB.
Clin Immunol. 2009 Nov;133(2):265-75.
Mechanisms linking osteoporosis with cardiovascular calcification.
Demer LL, Tintut Y.
Curr Osteoporos Rep. 2009 Jul;7(2):42-6.
Mechanical stress analysis of a rigid deposit in distensible material: A model of atherosclerotic calcification and plaque vulnerability.
Hoshino T, Chow LA, Hsu JJ, Perlowski AP, Abedin M, Tobis J, Tintut Y, Mal AK, Klug WS, Demer LL.
Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H802-10.
Systems biology of vascular calcification.
Sage AP, Tintut Y, Garfinkel A, Demer LL.
Trends Cardiovas Med. 2009 May;19(4):118-23. REVIEW.
T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.
Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y.
FEBS Lett. 2009 Apr 17;583(8):1344-8.

2008

Nanoscale architecture in atherosclerotic calcification.
Demer LL, Sage AP, Tintut Y.
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1882-4. Letter.
Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification.
Huang MS, Sage AP, Lu J, Demer LL, Tintut Y.
Biochem Biophys Res Commun. 2008 Sep 26;374(3):553-8.
Vitamin D and osteogenic differentiation in the artery wall.
Hsu JJ, Tintut Y, Demer LL.
Clin J Am Soc Nephrol. 2008 Sep;3(5):1542-7. REVIEW.
Vascular calcification: pathobiology of a multifaceted disease.
Demer LL, Tintut Y.
Circulation. 2008 Jun 3;117(22):2938-48. REVIEW.
Hyperlipidemia impairs osteoanabolic effects of PTH.
Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y.
J Bone Miner Res. 2008 Oct;23(10):1672-9.
Murine models of atherosclerotic calcification.
Hsu JJ, Tintut Y, Demer LL.
Curr Drug Targets. 2008 Mar;9(3):224-8. REVIEW.
Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.
Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL.
Circulation. 2008 Jan 22;117(3):411-20.
Vascular calcification.
Tintut Y, Huang M, Lu J, Tseng W, Garfinkel A, Demer LL.
J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):346. Letter.
A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells".
Demer LL, Tintut Y.
Free Radic Biol Med. 2008 Feb 15;44(4):504-5. Letter.

2007

Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.
Huang MS, Morony S, Lu J, Zhang Z, Bezouglaia O, Tseng W, Tetradis S, Demer LL, Tintut Y.
J Biol Chem. 2007 Jul 20;282(29):21237-43.
Mineralocorticoid receptor activation promotes vascular cell calcification.
Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME.
Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):799-805.

2006

Mechanical response of a calcified plaque model to fluid shear force.
Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK.
Ann Biomed Eng. 2006 Oct;34(10):1535-41.
Pitting phosphate transport inhibitors against vascular calcification.
Demer LL, Tintut Y
Circ Res. 2006 Apr 14;98(7):857-9. Letter.
N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways.
Abedin M, Lim J, Tang TB, Park D, Demer LL, Tintut Y.
Circ Res. 2006 Mar 31;98(6):727-9.

2005

Return to ectopia: stem cells in the artery wall.
Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1307-8. Letter.
Regulation of RANKL-induced osteoclastic differentiation by vascular cells.
Tintut Y, Abedin M, Cho J, Choe A, Lim J, Demer LL.
J Mol Cell Cardiol. 2005 Aug;39(2):389-93.
Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways.
Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y.
Circ Res. 2005 Mar 4;96(4):398-400.

2004

Skeleton key to vascular disease.
Demer LL, Abedin M.
J Am Coll Cardiol. 2004 Nov 16;44(10):1977-9. Letter.
Mesenchymal stem cells and the artery wall.
Abedin M, Tintut Y, Demer LL.
Circ Res. 2004 Oct 1;95(7):671-6. REVIEW.
Pattern formation by vascular mesenchymal cells.
Garfinkel A, Tintut Y, Petrasek D, Boström K, Demer LL.
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9247-50.